Serial interferon-γ release assays for screening and monitoring of tuberculosis infection during treatment with biologic agents
Identifieur interne : 001342 ( Main/Exploration ); précédent : 001341; suivant : 001343Serial interferon-γ release assays for screening and monitoring of tuberculosis infection during treatment with biologic agents
Auteurs : Rossana Scrivo [Italie] ; Ilaria Sauzullo [Italie] ; Fabio Mengoni [Italie] ; Giancarlo Iaiani [Italie] ; Anna Rita Vestri [Italie] ; Roberta Priori [Italie] ; Elisa Di Filippo [Italie] ; Manuela Di Franco [Italie] ; Francesca Romana Spinelli [Italie] ; Vincenzo Vullo [Italie] ; Claudio Maria Mastroianni [Italie] ; Guido Valesini [Italie]Source :
- Clinical Rheumatology [ 0770-3198 ] ; 2012-11-01.
English descriptors
Abstract
Abstract: Screening for latent tuberculosis infection (LTBI) prior to the prescribing of anti-TNF agents and monitoring for infection during treatment are recommended. The feasibility of novel screening tools, including QuantiFERON-TB Gold In-Tube (QFT-GIT), remains unclear in the setting of immunosuppression. The aim of this study was to evaluate the usefulness of serial QFT-GIT during biologic therapy to assess whether dynamic changes in IFN-γ levels may be helpful in identifying reactivation of LTBI or newly acquired TB. We conducted a prospective study on patient candidates to TNF inhibitors. QFT-GIT was performed at baseline and after 3 and 6 months since biologic onset. A further follow-up period of 6 months was observed. Among patients enrolled (n = 119; F = 69 %; median age = 47 years, range 18–80), 24 had at least 1 risk factor for LTBI. Ninety-six were taking immunosuppressants at the time of TB testing. At baseline, 5 patients displayed positive, 93 negative, and 21 indeterminate QFT-GIT results. We observed QFT-GIT conversions and reversions in 12 patients with LTBI and in 73 without LTBI. QFT-GIT results changed of 28 % at month 3 and of 21 % at month 6; the greatest change was observed in patients with indeterminate results that became negative (15 %; p < 0.02). No TB cases were detected. In conclusion, the routine use of both QFT-GIT and TST at screening seems not to give any advantage in the setting of patients awaiting biologics. In addition, the feasibility of serial QFT-GIT during biologic therapy needs definition since changes in IFN-γ levels may occur without a pathologic connotation.
Url:
DOI: 10.1007/s10067-012-2049-6
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002134
- to stream Istex, to step Curation: 002134
- to stream Istex, to step Checkpoint: 000351
- to stream Main, to step Merge: 001343
- to stream Main, to step Curation: 001342
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serial interferon-γ release assays for screening and monitoring of tuberculosis infection during treatment with biologic agents</title><author><name sortKey="Scrivo, Rossana" sort="Scrivo, Rossana" uniqKey="Scrivo R" first="Rossana" last="Scrivo">Rossana Scrivo</name></author><author><name sortKey="Sauzullo, Ilaria" sort="Sauzullo, Ilaria" uniqKey="Sauzullo I" first="Ilaria" last="Sauzullo">Ilaria Sauzullo</name></author><author><name sortKey="Mengoni, Fabio" sort="Mengoni, Fabio" uniqKey="Mengoni F" first="Fabio" last="Mengoni">Fabio Mengoni</name></author><author><name sortKey="Iaiani, Giancarlo" sort="Iaiani, Giancarlo" uniqKey="Iaiani G" first="Giancarlo" last="Iaiani">Giancarlo Iaiani</name></author><author><name sortKey="Vestri, Anna Rita" sort="Vestri, Anna Rita" uniqKey="Vestri A" first="Anna Rita" last="Vestri">Anna Rita Vestri</name></author><author><name sortKey="Priori, Roberta" sort="Priori, Roberta" uniqKey="Priori R" first="Roberta" last="Priori">Roberta Priori</name></author><author><name sortKey="Di Filippo, Elisa" sort="Di Filippo, Elisa" uniqKey="Di Filippo E" first="Elisa" last="Di Filippo">Elisa Di Filippo</name></author><author><name sortKey="Di Franco, Manuela" sort="Di Franco, Manuela" uniqKey="Di Franco M" first="Manuela" last="Di Franco">Manuela Di Franco</name></author><author><name sortKey="Spinelli, Francesca Romana" sort="Spinelli, Francesca Romana" uniqKey="Spinelli F" first="Francesca Romana" last="Spinelli">Francesca Romana Spinelli</name></author><author><name sortKey="Vullo, Vincenzo" sort="Vullo, Vincenzo" uniqKey="Vullo V" first="Vincenzo" last="Vullo">Vincenzo Vullo</name></author><author><name sortKey="Mastroianni, Claudio Maria" sort="Mastroianni, Claudio Maria" uniqKey="Mastroianni C" first="Claudio Maria" last="Mastroianni">Claudio Maria Mastroianni</name></author><author><name sortKey="Valesini, Guido" sort="Valesini, Guido" uniqKey="Valesini G" first="Guido" last="Valesini">Guido Valesini</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:71D2D40BFB93858AC2F628A3655E1297C173E8E5</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1007/s10067-012-2049-6</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-PS6N8XWG-0/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002134</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002134</idno><idno type="wicri:Area/Istex/Curation">002134</idno><idno type="wicri:Area/Istex/Checkpoint">000351</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000351</idno><idno type="wicri:doubleKey">0770-3198:2012:Scrivo R:serial:interferon:release</idno><idno type="wicri:Area/Main/Merge">001343</idno><idno type="wicri:Area/Main/Curation">001342</idno><idno type="wicri:Area/Main/Exploration">001342</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Serial interferon-γ release assays for screening and monitoring of tuberculosis infection during treatment with biologic agents</title><author><name sortKey="Scrivo, Rossana" sort="Scrivo, Rossana" uniqKey="Scrivo R" first="Rossana" last="Scrivo">Rossana Scrivo</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Interna e Specialità Mediche, Reumatologia, Sapienza Università di Roma, viale del Policlinico 155, 00161, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Italie</country></affiliation></author><author><name sortKey="Sauzullo, Ilaria" sort="Sauzullo, Ilaria" uniqKey="Sauzullo I" first="Ilaria" last="Sauzullo">Ilaria Sauzullo</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università di Roma, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Mengoni, Fabio" sort="Mengoni, Fabio" uniqKey="Mengoni F" first="Fabio" last="Mengoni">Fabio Mengoni</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università di Roma, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Iaiani, Giancarlo" sort="Iaiani, Giancarlo" uniqKey="Iaiani G" first="Giancarlo" last="Iaiani">Giancarlo Iaiani</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università di Roma, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Vestri, Anna Rita" sort="Vestri, Anna Rita" uniqKey="Vestri A" first="Anna Rita" last="Vestri">Anna Rita Vestri</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università di Roma, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Priori, Roberta" sort="Priori, Roberta" uniqKey="Priori R" first="Roberta" last="Priori">Roberta Priori</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Interna e Specialità Mediche, Reumatologia, Sapienza Università di Roma, viale del Policlinico 155, 00161, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Di Filippo, Elisa" sort="Di Filippo, Elisa" uniqKey="Di Filippo E" first="Elisa" last="Di Filippo">Elisa Di Filippo</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università di Roma, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Di Franco, Manuela" sort="Di Franco, Manuela" uniqKey="Di Franco M" first="Manuela" last="Di Franco">Manuela Di Franco</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Interna e Specialità Mediche, Reumatologia, Sapienza Università di Roma, viale del Policlinico 155, 00161, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Spinelli, Francesca Romana" sort="Spinelli, Francesca Romana" uniqKey="Spinelli F" first="Francesca Romana" last="Spinelli">Francesca Romana Spinelli</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Interna e Specialità Mediche, Reumatologia, Sapienza Università di Roma, viale del Policlinico 155, 00161, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Vullo, Vincenzo" sort="Vullo, Vincenzo" uniqKey="Vullo V" first="Vincenzo" last="Vullo">Vincenzo Vullo</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università di Roma, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Mastroianni, Claudio Maria" sort="Mastroianni, Claudio Maria" uniqKey="Mastroianni C" first="Claudio Maria" last="Mastroianni">Claudio Maria Mastroianni</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>UOC Malattie Infettive, Fondazione Eleonora Lorillard Spencer Cenci, Sapienza Università di Roma (Polo Pontino), Latina</wicri:regionArea><wicri:noRegion>Latina</wicri:noRegion></affiliation></author><author><name sortKey="Valesini, Guido" sort="Valesini, Guido" uniqKey="Valesini G" first="Guido" last="Valesini">Guido Valesini</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Interna e Specialità Mediche, Reumatologia, Sapienza Università di Roma, viale del Policlinico 155, 00161, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Rheumatology</title><title level="j" type="sub">Journal of the International League of Associations for Rheumatology</title><title level="j" type="abbrev">Clin Rheumatol</title><idno type="ISSN">0770-3198</idno><idno type="eISSN">1434-9949</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>London</pubPlace><date type="published" when="2012-11-01">2012-11-01</date><biblScope unit="volume">31</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1567">1567</biblScope><biblScope unit="page" to="1575">1575</biblScope></imprint><idno type="ISSN">0770-3198</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0770-3198</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-TNF</term><term>QuantiFERON-TB Gold In-Tube</term><term>Rheumatoid arthritis</term><term>Tuberculin skin test</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Screening for latent tuberculosis infection (LTBI) prior to the prescribing of anti-TNF agents and monitoring for infection during treatment are recommended. The feasibility of novel screening tools, including QuantiFERON-TB Gold In-Tube (QFT-GIT), remains unclear in the setting of immunosuppression. The aim of this study was to evaluate the usefulness of serial QFT-GIT during biologic therapy to assess whether dynamic changes in IFN-γ levels may be helpful in identifying reactivation of LTBI or newly acquired TB. We conducted a prospective study on patient candidates to TNF inhibitors. QFT-GIT was performed at baseline and after 3 and 6 months since biologic onset. A further follow-up period of 6 months was observed. Among patients enrolled (n = 119; F = 69 %; median age = 47 years, range 18–80), 24 had at least 1 risk factor for LTBI. Ninety-six were taking immunosuppressants at the time of TB testing. At baseline, 5 patients displayed positive, 93 negative, and 21 indeterminate QFT-GIT results. We observed QFT-GIT conversions and reversions in 12 patients with LTBI and in 73 without LTBI. QFT-GIT results changed of 28 % at month 3 and of 21 % at month 6; the greatest change was observed in patients with indeterminate results that became negative (15 %; p < 0.02). No TB cases were detected. In conclusion, the routine use of both QFT-GIT and TST at screening seems not to give any advantage in the setting of patients awaiting biologics. In addition, the feasibility of serial QFT-GIT during biologic therapy needs definition since changes in IFN-γ levels may occur without a pathologic connotation.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Scrivo, Rossana" sort="Scrivo, Rossana" uniqKey="Scrivo R" first="Rossana" last="Scrivo">Rossana Scrivo</name></region><name sortKey="Di Filippo, Elisa" sort="Di Filippo, Elisa" uniqKey="Di Filippo E" first="Elisa" last="Di Filippo">Elisa Di Filippo</name><name sortKey="Di Franco, Manuela" sort="Di Franco, Manuela" uniqKey="Di Franco M" first="Manuela" last="Di Franco">Manuela Di Franco</name><name sortKey="Iaiani, Giancarlo" sort="Iaiani, Giancarlo" uniqKey="Iaiani G" first="Giancarlo" last="Iaiani">Giancarlo Iaiani</name><name sortKey="Mastroianni, Claudio Maria" sort="Mastroianni, Claudio Maria" uniqKey="Mastroianni C" first="Claudio Maria" last="Mastroianni">Claudio Maria Mastroianni</name><name sortKey="Mengoni, Fabio" sort="Mengoni, Fabio" uniqKey="Mengoni F" first="Fabio" last="Mengoni">Fabio Mengoni</name><name sortKey="Priori, Roberta" sort="Priori, Roberta" uniqKey="Priori R" first="Roberta" last="Priori">Roberta Priori</name><name sortKey="Sauzullo, Ilaria" sort="Sauzullo, Ilaria" uniqKey="Sauzullo I" first="Ilaria" last="Sauzullo">Ilaria Sauzullo</name><name sortKey="Scrivo, Rossana" sort="Scrivo, Rossana" uniqKey="Scrivo R" first="Rossana" last="Scrivo">Rossana Scrivo</name><name sortKey="Spinelli, Francesca Romana" sort="Spinelli, Francesca Romana" uniqKey="Spinelli F" first="Francesca Romana" last="Spinelli">Francesca Romana Spinelli</name><name sortKey="Valesini, Guido" sort="Valesini, Guido" uniqKey="Valesini G" first="Guido" last="Valesini">Guido Valesini</name><name sortKey="Vestri, Anna Rita" sort="Vestri, Anna Rita" uniqKey="Vestri A" first="Anna Rita" last="Vestri">Anna Rita Vestri</name><name sortKey="Vullo, Vincenzo" sort="Vullo, Vincenzo" uniqKey="Vullo V" first="Vincenzo" last="Vullo">Vincenzo Vullo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001342 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001342 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:71D2D40BFB93858AC2F628A3655E1297C173E8E5
|texte= Serial interferon-γ release assays for screening and monitoring of tuberculosis infection during treatment with biologic agents
}}
| This area was generated with Dilib version V0.6.33. |  |